Research Fields

    We mainly focus on developing the molecular pathogenic mechanism of “Super Bacteria”, the efficient bactericidal mechanism of phages and functional phages. The PI was approved by the National Natural Science Fund for The Excellent Young Scholars, Hubei Province Fund for Distinguished Young Scholars and Hubei Province youth talent support program, and selected for the Outstanding Research Talents Development Program, Ministry of Agriculture and Rural Affairs of the People's Republic of China , Hubei Province youth talent support program.

     

  1. Molecular mechanism of pathogenic bacteria breaking through the blood-brain barrier and mechanisms for the spread of pathogenic bacteria in the host

    2.  

  2. Phage bank of zoonotic bacteria , synthetic phage and production technology of therapeutic phage

    3.  

  3. High-throughput screening of novel phage lysin or phage-derived peptide based on genomics technology

    4.  

  4. Discovery and mechanism study of new functional phage(editing intestinal flora, food safety prevention and control, tumor microenvironment, treatment of metabolic diseases)

    5.  

  5. Drug-resistant foodborne pathogenic bacteriophage resource library and green production technology (fermentation technology, nano-encapsulation technology)

    6.  

  6. Food safety rapid detection technology

    7.  

    Foundations

  1. Anthropozoonosis and Public Health, 2024.01-2026.12, National Natural Science Foundation of China Outstanding Youth Science Fund Project, PI:Jinquan LI

    2.  

  2. The Young Top-notch Talent Cultivation Program of Hubei Province, 2022-2023, PI:Jinquan LI

    3.  

  3. Mechanism of phage-host interaction and prediction of phage host range in Staphylococcus aureus, 2022-2024, Youth Project of Natural Science Foundation of Hubei Province, PI:Geng Zou

    4.  

  4. Mechanism of impermeable agent dependent phage lysin for effective lysis of drug-resistant Escherichia coli, 2021.1-2024.12, National Natural Science Foundation of China (General Program), PI:Jinquan LI

    5.  

  5. Mechanism of biofilm elimination in Salmonella enterica mediated by phage polysaccharide depolymerase, 2018.1-2021.12, National Natural Science Foundation of China (General Program), PI:Jinquan LI

    6.  

  6. Pathogenic mechanism of endothelin-converting enzymes of Streptococcus suis type 2, 2016.1-2018.12, Youth Project of National Natural Science Foundation of China, PI:Jinquan LI

    7.  

  7. Mechanism of effective phage lysin for antimicrobial-resistant Clostridium, 2019.1-2020.12, Science and Technology Innovation Special Project of Hubei Province(China-US Cooperation Special Project), PI:Jinquan LI

    8.  

  8. Vibrio parahaemolyticus contamination in crayfish in Hubei province, 2015.1-2016.12, Natural Science Foundation of Hubei Province, PI:Jinquan LI

    9.  

  9. Research on the mechanisms of antimicrobial resistance and transmission of important foodborne pathogenic bacteria, 2018.1-2021.12, National Key R&D Program of China, Core Member:Jinquan LI

    Latest Articles


  1. A Review and New Perspective on Oral Bacteriophages: Manifestations in the Ecology of Oral Diseases.
    Xinyu Guo, Xiaowan Wang, Jia Shi, Jiayi Ren, Jumei Zeng, Jinquan Li*, Yuqing Li*. Journal of Oral Microbiology, 2024, 16(1):2344272.
  2. Characterization of NMCR-3, NMCR-4 and NMCR-5, three novel non-mobile colistin resistance determinants: implications for MCR-3, MCR-7 and MCR-5 progenitors, respectively.
    Yating Guo, Geng Zou, Anusak Kerdsin, Constance Schultsz, Can Hu, Weicheng Bei, Huanchun Chen, Jinquan Li*, Yang Zhou*. Drug Resistance Updates, 2024, 101088.
  3. Application of a novel phage LPCS28 for biological control of Cronobacter sakazakii in milk and reconstituted powdered infant formula.
    Geng Zou, Libère Ndayishimiye, Lingxiang Xin, Manshan Cai, Longjian Zhang, Jie Li , Zhiyong Song, Renwei Wu, Yang Zhou, Yuanguo Shi, Yingwang Ye, Rui Zhou, Jinquan Li*. Food Research International, 2023, 172:113214.
  4. PlyKp104, a Novel Phage Lysin for the Treatment of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Other Gram-Negative ESKAPE Pathogens.
    Chad W Euler, Assaf Raz, Anaise Hernandez, Anna Serrano, Siyue Xu, Martin Andersson, Geng Zou, Yue Zhang, Vincent A Fischetti, Jinquan Li*. Antimicrob Agents Chemother, 2023, 17;67(5):e0151922.
  5. Combine thermal processing with polyvalent phage LPEK22 to prevent the Escherichia coli and Salmonella enterica contamination in food.
    Yue Zhang, Geng Zou, Md Sharifull Islam, Kun Liu, Suqiang Xue, Zhiyong Song, Yingwang Ye, Yang Zhou, Yuanguo Shi, Shaozhong Wei, Rui Zhou, Huanchun Chen, Jinquan Li*. Food Research International, 2022, 165:112454.
  6. Encapsulation and delivery of phage as a novel method for gut flora manipulation in situ: A review.
    Yufan Yang, Hu Du, Geng Zou, Zhiyong Song, Yang Zhou, Hao Li, Chen Tan, Huanchun Chen, Vincent A. Fischetti, Jinquan Li*. Journal of Controlled Release, 2022, 353:634-649.
  7. Phage controlling method against novel freshwater-derived Vibrio parahaemolyticus in ready-to-eat crayfish (Procambarus clarkii)
    Lin Teng, Geng Zou, Yang Zhou, Jie Li, Zhiyong Song, Xingxing Dong, Zhengxin Ma, Zhijie Zheng, Huanchun Chen, Jinquan Li*. Food Research International, 2022, 162:111986.
  8. Genomic analyses of Staphylococcus aureus isolated from yaks in Ganzi Tibetan Autonomous Prefecture, China
    Geng Zou, Marta Matuszewska, Fenglan Bai, Suya Wang, Shuang Wang, Huaixia Li, Yan Ke, Cheng Tang, Jinquan Li, Junni Tang, Rui Zhou*. Journal of Antimicrobial Chemotherapy, 2022, 77(4),910–920.
  9. The global emergence of a novel Streptococcus suis clade associated with human infections
    Xingxing Dong#, Yanjie Chao#, Yang Zhou, Rui Zhou, Wei Zhang, Vincent A. Fischetti, Xiaohong Wang, Ye Feng*, Jinquan Li*. EMBO Molecular Medicine, 2021, e13810
  10. In situ reduction triggers the highly sensitive detection of pesticide by classic gold nanoparticle and quantum dots nanocomposite
    Yu Jin , Ke Liu , Guangqiang Li, Chengfei Li, Zhidong Xiao, Chao Yuan*, Jinquan Li*. Analytica Chimica Acta, 2021, 1172:338679
  11. Application of a novel phage ZPAH7 for controlling multidrug-resistant Aeromonas hydrophila on lettuce and reducing biofilms
    Sharifull Islam, Md, Xiangwei Yang, Chad W. Euler, Xueqing Han, Jiahui Liu, Isrfil Hossen, Md, Yang Zhou, Jinquan Li*. Food Control, 2021, 122 :107785.
  12. Application of a novel phage vB_SalS-LPSTLL for biological control of Salmonella in foods
    Yating Guo#, Jie Li#, Md.Sharifull Islam, Ting Yan, Yang Zhou, Lu Liang, Ian F.Connerton, Kai Deng, Jinquan Li*. Food Research International, 2021, 147:110492.
  13. Decontamination of Escherichia coli O157:H7 on Fresh Romaine Lettuce Using a Novel Bacteriophage Lysin
    Siyue Xu, Edmondo Campisi, Jinquan Li*, Vincent A. Fischetti*. International Journal of Food Microbiology, 2021, 341:109068.
  14. Streptococcus suis Live Vaccine Suppresses Streptococcal Toxic Shock-Like Syndrome and Provides Sequence Type Independent Protection
    Zhiwei Li, Peixi Chang, Jiali Xu, Chen Tan, Xiaohong Wang, Weicheng Bei, Jinquan Li*. The Journal of Infectious Diseases, 2019, 219(3):448-458.
  15. Effects of Environmental and Management-Associated Factors on Prevalence and Diversity of Streptococcus suis in Clinically Healthy Pig Herds in China and the United Kingdom
    Geng Zou, Jianwei Zhou, Ran Xiao, Liangsheng Zhang, Yuting Cheng, Hui Jin, Lu Li, Lijun Zhang, Bin Wu, Ping Qian, Shaowen Li, Lixin Ren, Jinhong Wang, Olusegun Oshota, Juan Hernandez-Garcia, Thomas M. Wileman, Stephen Bentley, Lucy Weinert, Duncan J. Maskell, A. W. (Dan) Tucker*, Rui Zhou*. Applied and Environmental Microbiology, 2018, 84:e02590-17.